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Fertil Steril. 2007 Oct;88(4):1000-2. Epub 2007 Apr 6.

Korean ginseng induces spermatogenesis in rats through the activation of cAMP-responsive element modulator (CREM).

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Department of Pathology, College of Oriental Medicine, Kyungwon University, Seongnam, Korea.


The effect of Korean ginseng (ginseng) on spermatogenesis and cAMP-responsive element modulator (CREM) in rat testes was evaluated using sperm analysis, reverse transcription polymerase chain reaction, and Western blot analysis. The ginseng-treated rats exhibited significantly increased sperm count and motility with enhanced levels of CREM messenger RNA and protein. Ginseng appears to induce spermatogenesis via CREM activation in rat testes.

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