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Gen Pharmacol. 1994 Jan;25(1):193-9.

Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors.

Author information

1
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216-4045.

Abstract

1. Total saponin fraction decreased the affinity of specific [3H]muscimol binding without changes in Bmax. Ginsenoside Rb1 Rb2, Rc, Re, Rf and Rg1 inhibited the specific [3H]muscimol binding to the high-affinity site. 2. Total saponin fraction increased the affinity of specific [3H]flunitrazepam binding. Ginsenoside Re and Rf enhanced specific [3H]flunitrazepam binding. 3. Total saponin fraction decreased the affinity of specific [35S]TBPS binding without changes in Bmax. Ginsenosides did not affect specific or non-specific [35S]TBPS binding. 4. Total saponin fraction decreased the affinity of specific [3H]baclofen binding without changes in Bmax. Ginsenoside Rc inhibited specific [3H]baclofen binding.

PMID:
8026706
DOI:
10.1016/0306-3623(94)90032-9
[Indexed for MEDLINE]

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